New Letters Added To the Genetic Alphabet

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An anonymous reader writes with this excerpt from Quanta Magazine: [A]fter decades of work, [organic chemist Steven] Benner’s team has synthesized artificially enhanced DNA that functions much like ordinary DNA, if not better. In two papers published in the Journal of the American Chemical Society last month, the researchers have shown that two synthetic nucleotides called P and Z fit seamlessly into DNA’s helical structure, maintaining the natural shape of DNA. Moreover, DNA sequences incorporating these letters can evolve just like traditional DNA, a first for an expanded genetic alphabet. In fact, the article continues, these new nucleotides can actually outperform their natural counterparts: “When challenged to evolve a segment that selectively binds to cancer cells, DNA sequences using P and Z did better than those without.” Read more of this story at Slashdot.

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New Letters Added To the Genetic Alphabet

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