Current methods for detecting the antibodies that indicate HIV infection are agonizingly slow and cumbersome. However a new DNA nanomachine developed by an international team of researchers (and funded, in part, by the Bill & Melinda Gates Foundation) could shorten the process to a matter of minutes. The DNA-based nanomachine is designed and synthesized to recognize and bind with a specific target antibody, even within biologically-dense and complex samples like blood. When these “machines” do bind with the target antibody, the joining causes a structural change that generates a little burst of light. A test that used to require hours of careful, complex and downright expensive prep-work could now take as little as five minutes. And the sooner that doctors are aware of the infection, the sooner they can start treating it . What’s more, these nanomachines can easily be customized to detect a wide variety of antibodies. “Our modular platform provides significant advantages over existing methods for the detection of antibodies, ” Prof. Vallée-Bélisle of the University of Montreal, a senior co-author of the paper, said in a statement. “It is rapid, does not require reagent chemicals, and may prove to be useful in a range of different applications such as point-of-care diagnostics and bioimaging.” The team hopes to further develop the technology, making the signals even easier to detect. “For example, we could adapt our platform so that the signal of the nanoswitch may be read using a mobile phone , ” Simona Ranallo, University of Rome PhD student and first-author of the paper, said in a statement. “This will make our approach really available to anyone! We are working on this idea and we would like to start involving diagnostic companies.” [Image Credit: lede – LightRocket via Getty Images, inline – Marco Tripodi] Source: University of Montreal
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DNA nanomachine detects HIV antibodies in minutes, not hours
theshowmecanuck writes “According to the Montreal Gazette, ‘The owner and operator of a well-known ‘real gore’ website is charged with corrupting morals for posting a video allegedly depicting the murder of student Jun Lin by Luka Magnotta. Magnotta, 30, is currently in custody charged with first-degree murder in the death of the 33-year-old Chinese international student, who was killed in Montreal in May 2012. The victim’s severed limbs were then mailed to political parties and elementary schools, and his torso found inside a discarded suitcase.’ A news interview with the detective in charge of the case, airing on CTV as I type this, says he believes the web site hosts a lot of racist content and unimaginable violence. You should note that Canada has less free speech than in America (we have ‘hate crime laws’), but there will likely be some arguments in this vein. The charge against the operator is quite rare and no-one so far remembers it ever being used before.” Read more of this story at Slashdot. 
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