A team of scientists from the University of California, San Francisco only wanted to slow down mice embryos’ cell growth in the lab. Instead, they managed to completely pause their development, putting the blastocysts (very early embryos) in suspended animation for a month. What’s more, they found that the process can put stem cells derived from the blastocysts in suspended animation, as well. Okay, let’s face it: that doesn’t sound nearly as cool as putting humans in suspended animation. But their finding still has huge implications for various fields of medicine. Doctors could develop a way to suspend embryos for IVF and scientists could find a method to slow down aging, among other possibilities. Helps that the researchers were able to prove that the embryos can develop normally even after a pause in their growth. Team member Ramalho-Santos from the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research said: “It was completely surprising. We were standing around in the tissue culture room, scratching our heads, and saying wow, what do we make of this? To put it in perspective, mouse pregnancies only last about 20 days, so the 30-day-old ‘paused’ embryos we were seeing would have been pups approaching weaning already if they’d been allowed to develop normally.” So, what exactly did the team do that led to their finding? They used a drug that inhibited the activities of a protein called mTOR, which regulates different cellular processes. By inhibiting the protein, they also inhibit the cells’ activities. In the future, the researchers want to explore mTOR inhibitors’ capability to pause stem cells’ activities in the late stages of their development, which could be used to repair or replace organs. And since other studies already showed that mTOR inhibitors can extend the lives of mice, the researchers want to explore their possible uses in aging research. Source: University of California, San Francisco
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Scientists put mouse embryos in suspended animation for a month
From a Bloomberg report:The aloe vera gel many Americans buy to soothe damaged skin contains no evidence of aloe vera at all. Samples of store-brand aloe gel purchased at national retailers Wal-Mart, Target and CVS showed no indication of the plant in various lab tests. The products all listed aloe barbadensis leaf juice — another name for aloe vera — as either the No. 1 ingredient or No. 2 after water. There’s no watchdog assuring that aloe products are what they say they are. The U.S. Food and Drug Administration doesn’t approve cosmetics before they’re sold and has never levied a fine for selling fake aloe. That means suppliers are on an honor system, even as the total U.S. market for aloe products, including drinks and vitamins, has grown 11 percent in the past year to $146 million, according to Chicago-based market researcher SPINS LLC. “You have to be very careful when you select and use aloe products, ” said Tod Cooperman, president of White Plains, New York-based ConsumerLab.com, which has done aloe testing. Aloe’s three chemical markers — acemannan, malic acid and glucose — were absent in the tests for Wal-Mart, Target and CVS products conducted by a lab hired by Bloomberg News. The three samples contained a cheaper element called maltodextrin, a sugar sometimes used to imitate aloe. The gel that’s sold at another retailer, Walgreens, contained one marker, malic acid, but not the other two. Read more of this story at Slashdot.