The concept of using stem cells for transplants just became a truly practical reality: a Japanese man with age-related macular degeneration has received the first transplant of stem cells from another human donor. Doctors repurposed the donor’s skin cells by turning them into induced pluripotent stem cells (that is, forced into a state where they can become many kinds of cells) that then became retinal cells. If all goes according to plan with the multi-step procedure, these fresh cells will halt the degeneration and preserve the patient’s remaining eyesight. This isn’t the first time that human stem cells have been used. There was another macular degeneration treatment in 2014. However, the prior example revolved around taking samples from the patient’s own skin. That’s risky when they may be dealing with genetic flaws that could hinder the treatment. So long as the newest procedure proves a long-term success, it opens the door to plucking cells from healthier candidates. And importantly, there are plans for this to become relatively commonplace. Researcher Shinya Yamanaka is developing a stem cell bank that would give recipients immediate treatment, instead of having to wait months to cultivate cells from a matching candidate. This would only potentially address about 30 to 50 percent of the Japanese population, but that could be enough to improve the quality of life for many people. Source: Nature , NEJM
See more here:
Man receives someone else’s reprogrammed stem cells
vinces99 writes “Scientists have unveiled a comprehensive portrait of the genome of the world’s first immortal cell line, known as HeLa, derived in 1951 from an aggressive cervical cancer that killed Henrietta Lacks, a 31-year-old African-American woman. The cells, taken without her or her family’s knowledge, were pivotal in developing the polio vaccine, in vitro fertilization and cloning, and were the subject of a 2010 New York Times best-seller ‘The Immortal Life of Henrietta Lacks.’ The Lacks family has never been compensated and, until this new University of Washington study, has never had a say in how the information is used. The study, published Aug. 8 in Nature, pieced together the complicated insertion of the human papillomavirus genome, which contains its own set of cancer genes, into Lacks’ genome near an ‘oncogene, ‘ a naturally occurring gene that can cause cancer when altered. Scientists had never succeeded in reproducing cells in a culture until the HeLa cells, which reproduced an entire generation every 24 hours and never stopped. The cells allowed scientists to perform experiments without using a living human. The researchers discovered that the genome of the HeLa cell line, which has been replicated millions, if not billions of times, has remained relatively stable.” Read more of this story at Slashdot.