Fingernail-sized chip can repair damaged tissue in seconds

A new device can begin repairing damaged organs in seconds, heralding a major breakthrough for life-saving medicine. Developed at Ohio State University , the technology known as tissue nanotransfection (TNT) uses a small coin-sized silicone chip that “injects” genetic code into skin cells, converting them from one type to another. During the initial testing phase, researchers were able to reprogram skin cells into vascular cells on a mouse that had a badly injured leg with no blood flow. Within one week active blood vessels appeared around the leg and within two weeks the leg had been completely restored. A mouse that had suffered a stroke was also saved, suggesting this technology can be applied to organs and nerve cells, as well as tissue. It’s the first time cells have been reprogrammed in a live body. The technology weighs less than 100 grams and has a long shelf life. It’s completely non-invasive — the genetic code is delivered by zapping the device with a small electrical charge that’s barely felt by the patient — and the procedure can be carried out without access to a lab or hospital . This means it will have a significant impact on the lives of those involved in medical emergencies where time is a crucial factor, such as car crash victims and soldiers injured in the field. It’s still waiting for FDA approval, but researchers expect testing on humans to start within the year. Via: USA Today Source: Ohio State University

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Fingernail-sized chip can repair damaged tissue in seconds

Surgeons complete first uterus transplants from live donors in US

A team of surgeons at Baylor University Medical Center in Dallas have achieved something that hadn’t previously been done in the US. With the help of a Swedish surgical team, doctors performed the first uterus transplants from living donors . The experimental procedures took place between September 14th and 22nd with four total transplants. While the first three were unsuccessful, the fourth patient is showing positive results based on follow-up tests. The transplanted uteri were removed from those first three patients and they’re expected to resume normal activity soon. For the fourth patient, tests indicate good blood flow to the uterus with no signs of rejection or infection. “We are cautiously optimistic that she could ultimately become the first uterine transplant recipient in the US to make it to the milestone of uterine functionality, ” a statement from Baylor University Medical Center explained. 16 uterine transplants have been performed around the world thus far. In fact, the Swedish team that assisted doctors at Baylor are considered experts on the procedure. There have been five births following procedures they’ve completed. Following these most recent transplants, both surgical teams say they’ve gained valuable knowledge from the three unsuccessful cases that will prove beneficial to future operations. Changes will include updates to protocols and post-op management with special attention to the thickness of the uterine veins. Back in February, the Cleveland Clinic performed the first uterus transplant in the US. In that case, the 26-year-old recipient would have needed to have the organ removed after one or two pregnancies due to medications that kept her body from rejecting it. Due to compromised blood flow caused by an infection in the weeks that followed, the transplanted uterus was removed in March. Via: CNN Source: Baylor University Medical Center (1) , (2)

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Surgeons complete first uterus transplants from live donors in US