A team of scientists from the University of California, San Francisco only wanted to slow down mice embryos’ cell growth in the lab. Instead, they managed to completely pause their development, putting the blastocysts (very early embryos) in suspended animation for a month. What’s more, they found that the process can put stem cells derived from the blastocysts in suspended animation, as well. Okay, let’s face it: that doesn’t sound nearly as cool as putting humans in suspended animation. But their finding still has huge implications for various fields of medicine. Doctors could develop a way to suspend embryos for IVF and scientists could find a method to slow down aging, among other possibilities. Helps that the researchers were able to prove that the embryos can develop normally even after a pause in their growth. Team member Ramalho-Santos from the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research said: “It was completely surprising. We were standing around in the tissue culture room, scratching our heads, and saying wow, what do we make of this? To put it in perspective, mouse pregnancies only last about 20 days, so the 30-day-old ‘paused’ embryos we were seeing would have been pups approaching weaning already if they’d been allowed to develop normally.” So, what exactly did the team do that led to their finding? They used a drug that inhibited the activities of a protein called mTOR, which regulates different cellular processes. By inhibiting the protein, they also inhibit the cells’ activities. In the future, the researchers want to explore mTOR inhibitors’ capability to pause stem cells’ activities in the late stages of their development, which could be used to repair or replace organs. And since other studies already showed that mTOR inhibitors can extend the lives of mice, the researchers want to explore their possible uses in aging research. Source: University of California, San Francisco
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Scientists put mouse embryos in suspended animation for a month
MojoKid writes: Intel is laying out its roadmap to advance artificial intelligence performance across the board. Nervana Systems, a company that Intel acquired just a few months ago, will play a pivotal role in the company’s efforts to make waves in an industry dominated by GPU-based solutions. Intel’s Nervana chips incorporate technology (which involves a fully-optimized software and hardware stack) that is specially tasked with reducing the amount of time required to train deep-learning models. Nervana hardware will initially be available as an add-in card that plugs into a PCIe slot, which is the quickest way for Intel to get this technology to customers. The first Nervana silicon, codenamed Lake Crest, will make its way to select Intel customers in H1 2017. Intel is also talking about Knights Mill, which is the next generation of the Xeon Phi processor family. The company claims that Knights Mill will deliver a 4x increase in deep learning performance compared to existing Xeon Phi processors and the combined solution with Nervana will offer orders of magnitude gains in deep learning performance. “We expect the Intel Nervana platform to produce breakthrough performance and dramatic reductions in the time to train complex neural networks, ” said Diane Bryant, Executive VP of Intel’s Data Center Group. “We expect Nervana’s technologies to produce a breakthrough 100-fold increase in performance in the next three years to train complex neural networks, enabling data scientists to solve their biggest AI challenges faster, ” added Intel CEO Brian Krzanich. Read more of this story at Slashdot.