A nanoparticle-coated skin patch could treat obesity and diabetes

A new study out today in ACS Nano presents an interesting and effective way to reduce fat stores in the body. Researchers at Columbia University and the University of North Carolina showed that a patch loaded with nanoparticles could reduce fat, increase energy expenditure and ameliorate type-2 diabetes in obese mice. The patch consists of an array of microscopic needles that help deliver drugs enclosed in nanoparticles directly into fat lying beneath the skin. Those drugs help turn white fat, which stores energy, into brown fat, which burns energy. Humans have both types, but as we age, we lose more and more of our brown fat, leaving mostly white fat behind. Therefore, it’s harder to get rid of the fat we have once we store it. Turning white fat into brown — a process called browning — has been a concept explored by researchers looking to treat obesity and diabetes , but earlier efforts have been largely done with pills or injections, which can cause a number of side effects since they deliver the drugs to the entire body. This patch, however, can concentrate the drug to just the area with the fat. And when they tested it on obese rats, putting a patch with drug on one side and a patch without drug on the other, researchers found that the drug side showed around 30 percent reductions of a particular type of white fat. Additionally, genes associated with brown fat were upregulated in the treated side, meaning the changes appeared to be due to a browning of the white fat stores. The patches even had an effect in healthy mice, leading to increased metabolic activity and upregulated brown fat genes. The research team is now working on figuring out which drugs work best and at which concentrations. The treatment isn’t ready for human testing, but these first results seem promising. “Many people will no doubt be excited to learn that we may be able to offer a noninvasive alternative to liposuction for reducing love handles, ” Li Qiang, one of the lead researchers of the study, said in a statement . “What’s much more important is that our patch may provide a safe and effective means of treating obesity and related metabolic disorders such as diabetes.” Via: Phys.org Source: ACS Nano , Columbia University

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A nanoparticle-coated skin patch could treat obesity and diabetes

Azure Confidential Computing will keep data secret, even from Microsoft

Enlarge / The Trusted Execution Environment means that, even if the application and operating system are compromised, the green code and data can’t be accessed. (credit: Microsoft ) Microsoft announced today a new feature coming to its Azure cloud platform named “Confidential Compute.” The feature will allow applications running on Azure to keep data encrypted not only when it’s at rest (in storage) or in transit (over a network) but when it’s being computed on in-memory. This ability to encrypt data when it’s in-use means that it can be kept secure even from Microsoft’s administrators, government warrants, and hackers. Confidential Computing will have two modes: one is built on virtual machines, while the other uses the SGX (“Software Guard Extensions”) feature found in Intel’s recently introduced Skylake-SP Xeon processors. Both modes will allow applications to ringfence certain parts of their code and data so that they operate in a “trusted execution environment” (TEE). Code and data that are inside a TEE cannot be inspected from outside the TEE. The virtual machine mode uses the Virtual Secure Mode (VSM) functionality of Hyper-V that was introduced in Windows 10 and Windows Server 2016. With VSM, most parts of an application will run in a regular virtual machine atop a regular operating system. The protected, TEE parts will run in a separate virtual machine containing only a basic stub operating system (enough that it can communicate with the regular VM) and only those parts of the application code that need to handle the sensitive data. Read 4 remaining paragraphs | Comments

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Azure Confidential Computing will keep data secret, even from Microsoft

Rare white giraffes spotted in Kenya

In early June, conservation rangers with the Hirola Conservation Program in Kenya first spotted a white female and baby giraffe. In early August, they were able to capture this footage of the elusive pair. Like that translucent-shelled lobster that was recently pulled in, these giraffes are not albino but have a genetic condition called Leucism. That means they a partial loss of pigmentation in their skin cells. If you look closely, you can see a familiar, though faded, reticulation on the calf’s neck. A blogger for Hirola writes : In this very sighting, in Ishaqbini, there was a mother and a juvenile The communities within Ishaqbini have mixed reactions to the sighting of this leucistic giraffe and most of the elders report that they have never seen this before. ‘This is new to us” says bashir one of the community rangers who alerted us when they sighted the white giraffe. “I remember when I was a kid, we never saw them” he added. “It must be very recent and we are not sure what is causing it” he said. ( National Geographic )

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Rare white giraffes spotted in Kenya

‘Cowboy Bebop’ director made a ‘Blade Runner’ animated short

Over 35 years since Blade Runner came out, its sequel is almost upon us. Blade Runner: 2049 hits theaters in less than a month. And (depending on who you ask) it’s either been too long a wait, or it should never have seen the light of day. For anyone still on the fence, the film’s marketing blitz is on hand to help part you from your cash. We’ve seen trailers , a VR tie-in , and a short prequel featuring Jared Leto’s impeccable beard. Just in the last 24 hours, a new promo starring Dave Bautista has hit the web, along with another (more exciting) teaser: Sony Pictures just unveiled a new anime spinoff for the upcoming film. Blade Runner Black Out 2022, as it’s known, will be directed by none other than Shinichiro Watanabe. For all those out of the loop, he’s the legend behind Cowboy Bebop and Samurai Champloo . As you can tell by its title, the anime short will serve as a prequel to the upcoming film, with the action taking place during a power outage, according to NetLab . The brief video above also offers a closer look at its test animation, concept art, and some actual footage. “The work that has influenced me the most in my anime profession would be, of course, Blade Runner , ” says Watanabe in the video. That’s high praise. But, Ridley Scott’s sci-fi classic left its imprint all over pop culture, so it’s no surprise its reach extends to Japanese animation. Anime studio Cygames Pictures is producing the short, and Shukou Murase ( Halo Legends , Mobile Suit Gundam Wing ) is on hand as character designer and animation director. Plus, electronic mastermind Flying Lotus will be in charge of the score. You can watch Blade Runner Black Out 2022 in full on the Sony Pictures Japan YouTube channel on September 26th. Source: Sony Pictures Japan (YouTube)

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‘Cowboy Bebop’ director made a ‘Blade Runner’ animated short

Bitcoin Plummets Below $3,000 on Rising China Worries

Bitcoin dropped below $3, 000 on Friday as the cryptocurrency extended a brutal eight-day sell-off that has reduced its value against the dollar by a third. Financial Times reports: The currency traded as low as $2, 972, marking a 36 per cent fall from bitcoin’s close on September 7, and a collapse of 40 per cent from the highs struck earlier this month. The latest bout of selling came after BTCChina, one of the country’s biggest bitcoin exchanges, said it would halt trading at the end of the month. Focus has now shifted to the communist country’s other two big exchanges: OKCoin and Huobi. Alternative source. Read more of this story at Slashdot.

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Bitcoin Plummets Below $3,000 on Rising China Worries

Every Major Advertising Group Is Blasting Apple for Blocking Cookies in the Safari Browser

The biggest advertising organizations say Apple will “sabotage” the current economic model of the internet with plans to integrate cookie-blocking technology into the new version of Safari. Marty Swant, reporting for AdWeek: Six trade groups — the Interactive Advertising Bureau, American Advertising Federation, the Association of National Advertisers, the 4A’s and two others — say they’re “deeply concerned” with Apple’s plans to release a version of the internet browser that overrides and replaces user cookie preferences with a set of Apple-controlled standards. The feature, which is called “Intelligent Tracking Prevention, ” limits how advertisers and websites can track users across the internet by putting in place a 24-hour limit on ad retargeting. In an open letter expected to be published this afternoon, the groups describe the new standards as “opaque and arbitrary, ” warning that the changes could affect the “infrastructure of the modern internet, ” which largely relies on consistent standards across websites. The groups say the feature also hurts user experience by making advertising more “generic and less timely and useful.” Read more of this story at Slashdot.

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Every Major Advertising Group Is Blasting Apple for Blocking Cookies in the Safari Browser

Quantum computers reach deeper, find ground state of simple hydrides

Enlarge (credit: IBM ) Every time we discuss quantum computers, the headline tends to be that someone, somewhere is going to use the quantum to break your encryption and steal your student loan. If only that were true. But it is probably more realistic to think about quantum computers being used to solve quantum problems. And this has been demonstrated with recent chemistry calculations using a tiny quantum computer. If solving quantum problems with quantum computers sounds a bit circular, well, it is, but it is also practical. Think of it like this: every protein in your body has the structure it has because of quantum mechanics. And a physicist who is clever, but not intelligent, can write down an exact equation that describes that protein. But not even the most intelligent can solve that equation. Understanding molecules is hard A lazier physicist would write a computer script to solve the equation. But that won’t work either, because the time it takes to solve an exact description of the molecule will take longer than it takes to go from Big Bang to Heat Death. So we live with approximations. Approximations that are mostly pretty good but sometimes fail spectacularly. And, for some molecules, those approximations don’t speed up calculations very much at all. Read 13 remaining paragraphs | Comments

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Quantum computers reach deeper, find ground state of simple hydrides

Body of mysterious fang-toothed, snake-like, eel-like creature identified: it’s a fangtooth snake-eel

Preeti Desai of the National Audubon Society came across a dead creature on the beach in Texas City, Texas. She took photos and tweeted: “Okay, biology twitter, what the heck is this?? Found on a beach in Texas City, TX. #wildlifeid.” The consensus is that the fang-toothed, snake-like, eel-like creature is a fangtooth snake-eel . From Yahoo : Biologist Dr. Kenneth Tighe of the Smithsonian National Museum of Natural History was able to answer Desai’s question after the request was passed along to him. Tighe believed the creature to be an Aplatophis chauliodus, which is also known as a fangtooth snake-eel or tusky eel. The toothy creature’s scientific name translates to “terrible serpent.” “It might be [a] Bathyuroconger vicinus or Xenomystax congroides,” Tighe told EarthTouch News on Thursday. “All three of these species occur off Texas and have large fang-like teeth. Too bad you can’t clearly see the tip of the tail. That would differentiate between the ophichthid and the congrids.” Okay, biology twitter, what the heck is this?? Found on a beach in Texas City, TX. #wildlifeid pic.twitter.com/9IUuuL65qh — Preeti Desai

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Body of mysterious fang-toothed, snake-like, eel-like creature identified: it’s a fangtooth snake-eel

Malicious apps with >1 million downloads slip past Google defenses twice

Enlarge / One of the fee-based services ExpensiveWallpaper apps subscribed users to. Researchers recently found at least 50 apps in the official Google Play market that made charges for fee-based services without the knowledge or permission of users. The apps were downloaded as many as 4.2 million times. Google quickly removed the apps after the researchers reported them, but within days, apps from the same malicious family were back and infected more than 5,000 devices. The apps, all from a family of malware that security firm Check Point calls ExpensiveWall, surreptitiously uploaded phone numbers, locations, and unique hardware identifiers to attacker-controlled servers. The apps then used the phone numbers to sign up unwitting users to premium services and to send fraudulent premium text messages, a move that caused users to be billed. Check Point researchers didn’t know how much revenue was generated by the apps. Google Play showed the apps had from 1 million to 4.2 million downloads. Packing heat ExpensiveWall—named after one of the individual apps called LovelyWall—used a common obfuscation technique known as packing. By compressing or encrypting the executable file before it’s uploaded to Play, attackers can hide its maliciousness from Google’s malware scanners. A key included in the package then reassembled the executable once the file was safely on the targeted device. Although packing is more than a decade old, Google’s failure to catch the apps, even after the first batch was removed, underscores how effective the technique remains. Read 3 remaining paragraphs | Comments

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Malicious apps with >1 million downloads slip past Google defenses twice

Backdoor Found In WordPress Plugin With More Than 200,000 Installations

According to Bleeping Computer, a WordPress plug that goes by the name Display Widgets has been used to install a backdoor on WordPress sites across the internet for the past two and a half months. While the WordPress.org team removed the plugin from the official WordPress Plugins repository, the plugin managed to be installed on more than 200, 000 sites at the time of its removal. The good news is that the backdoor code was only found between Display Widgets version 2.6.1 (released June 30) and version 2.6.3 (released September 2), so it’s unlikely everyone who installed the plugin is affected. WordPress.org staff members reportedly removed the plugin three times before for similar violations. Bleeping Computer has compiled a history of events in its report, put together with data aggregated from three different investigations by David Law, White Fir Design, and Wordfence. The report adds: The original Display Widgets is a plugin that allowed WordPress site owners to control which, how, and when WordPress widgets appear on their sites. Stephanie Wells of Strategy11 developed the plugin, but after switching her focus to a premium version of the plugin, she decided to sell the open source version to a new developer who would have had the time to cater to its userbase. A month after buying the plugin in May, its new owner released a first new version — v2.6.0 — on June 21. Read more of this story at Slashdot.

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Backdoor Found In WordPress Plugin With More Than 200,000 Installations