Enlarge / Sequence on a stick. (credit: Oxford Nanopore ) A few years back, a company called Oxford Nanopore announced it was developing a radically different way of sequencing DNA. Its approach involved taking single strands of the double helix and stuffing them through a protein pore. With a small bit of current flowing across the pore, the four bases of DNA each created a distinct (if tiny) change in the voltage as it passed through. These could be used to read the DNA one base at a time as it wiggled through the pore. After several years of slow progress, Oxford Nanopore announced that its sequencing hardware would be as distinctive as its wetware: a USB device that could fit comfortably in a person’s hand. As the first devices went out to users, it became clear that the device had some pros and cons . On the plus side, the device was quick and could be used without requiring a large facility to support it. It could also read very long stretches of DNA at once. But the downside was significant: it made lots of mistakes. With a few years of experience, people are now starting to learn to make the most of the devices, as demonstrated by a new paper in which researchers use it to help sequence a human genome. By using the machine’s long reads—in one case, nearly 900,000 bases from one DNA molecule—the authors were able to get data out of areas of the human genome that resisted characterization before. And they were able to distinguish between the two sets of chromosomes (one from mom, one from dad) and locate areas of epigenetic control in many areas of the genome. Read 12 remaining paragraphs | Comments
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Pocket-sized DNA reader used to scan entire human genome sequence
schwit1 shares a report from Seeker: An ice-free corridor between the Americas and Asia opened up about 12, 500 years ago, allowing humans to cross over the Bering land bridge to settle what is now the United States and places beyond to the south. History books have conveyed that information for years to explain how the Americas were supposedly first settled by people, such as those from the Clovis culture. At least one part of the Americas was already occupied by humans before that time, however, says new research on the skeleton of a male youth found in Chan Hol cave near Tulum, Mexico. Dubbed the Young Man of Chan Hol, the remains date to 13, 000 years ago, according to a paper published in the journal PLOS ONE. How he arrived at the location remains a great mystery given the timing and the fact that Mexico is well over 4, 000 miles away from the Bering land crossing. For the new study, Gonzalez, Stinnesbeck, and their colleagues dated the Young Man of Chan Hol’s remains by analyzing the bones’ uranium, carbon, and oxygen isotopes, which were also found in stalagmite that had grown through the pelvic bone. The scientists believe that the resulting age of 13, 000 years could apply to at least two other skeletons found in caves around Tulum: a teenage female named Naia and a 25-30-year-old female named Eve of Naharon. Gonzalez said that the shape of the skulls suggests that Eve and the others “have more of an affinity with people from Southeast Asia.” He and his team further speculated that the individuals could have originated in Indonesia. Read more of this story at Slashdot. 
