A new study published in the journal Scientific Reports describes research “designed to generate muscle from a newly established pig stem-cell line, rather than from primary cells taken directly from a pig, ” says co-author Dr. Nicholas Genovese, a stem-cell biologist. “This entailed understanding the biology of relatively uncharacterized and recently-derived porcine induced pluripotent stem cell lines. What conditions support cell growth, survival and differentiation? These are all questions I had to figure out in the lab before the cells could be turned into muscle.” Digital Trends reports: It may not sound like the most appetizing of foodstuffs, but pig skeletal muscle is in fact the main component of pork. The fact that it could be grown from a stem-cell line, rather than from a whole pig, is a major advance. This is also true of the paper’s second big development: the fact that this cultivation of pig skeletal muscle didn’t use animal serum, a component which has been used in other livestock muscle cultivation processes. [Genovese] acknowledges that there are other non-food-related possibilities the work hints at. “There is a contingent interest in using the pig as a model to study disease and test regenerative therapies for human conditions, ” he said. Read more of this story at Slashdot.
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Scientists Use Stem Cells To Grow Animal-Free Pork In a Lab
An anonymous reader quotes a report from Ars Technica: In 1935, scientists predicted that the simplest element, hydrogen, could also become metallic under pressure, and they calculated that it would take 25 GigaPascals to force this transition (each Gigapascal is about 10, 000 atmospheres of pressure). That estimate, in the words of the people who have finally made metallic hydrogen, “was way off.” It took until last year for us to reach pressures where the normal form of hydrogen started breaking down into individual atoms — at 380 GigaPascals. Now, a pair of Harvard researchers has upped the pressure quite a bit more, and they have finally made hydrogen into a metal. All of these high-pressure studies rely on what are called diamond anvils. This hardware places small samples between two diamonds, which are hard enough to stand up to extreme pressure. As the diamonds are forced together, the pressure keeps going up. Current calculations suggested that metallic hydrogen might require just a slight boost in pressure from the earlier work, at pressures as low as 400 GigaPascals. But the researchers behind the new work, Ranga Dias and Isaac Silvera, discovered it needed quite a bit more than that. In making that discovery, they also came to a separate realization: normal diamonds weren’t up to the task. “Diamond failure, ” they note, “is the principal limitation for achieving the required pressures to observe SMH, ” where SMH means “solid metallic hydrogen” rather than “shaking my head.” The team came up with some ideas about what might be causing the diamonds to fail and corrected them. One possibility was surface defects, so they etched all diamonds down by five microns to eliminate these. Another problem may be that hydrogen under pressure could be forced into the diamond itself, weakening it. So they cooled the hydrogen to slow diffusion and added material to the anvil that absorbed free hydrogen. Shining lasers through the diamond seemed to trigger failures, so they switched to other sources of light to probe the sample. After loading the sample and cranking up the pressure (literally — they turned a handcrank), they witnessed hydrogen’s breakdown at high pressure, which converted it from a clear sample to a black substance, as had been described previously. But then, somewhere between 465 and 495 GigaPascals, the sample turned reflective, a key feature of metals The study has been published in the journal Science. Read more of this story at Slashdot.
randomErr quotes a report from Quartz: In the last 10 years, researchers have developed specific sniff tests for diagnosing tuberculosis, hypertension, cystic fibrosis, and even certain types of cancer. A group of global researchers led by Hossam Haick at the Israel Institute of Technology have taken the idea a step further. They’ve built a device — a kind of breathalyzer — that is compact and can diagnose up to 17 diseases from a single breath of a patient. The breathalyzer has an array of specially created gold nanoparticles, which are sized at billionths of a meter, and mixed with similar-sized tubes of carbon. These together create a network that is able to interact differently with each of the nearly 100 volatile compounds that each person breaths out (apart from gases like nitrogen, oxygen, and carbon dioxide). Haick’s team collected 2, 800 breaths from more than 1, 400 patients who were each suffering from at least one of 17 diseases (in three classes: cancer, inflammation, and neurological disorders). Each sample of the disease was then passed through the special breathalyzer, which then produced a dataset of the types of chemicals it could detect and in roughly what quantities. The team then applied artificial intelligence to the dataset to search for patterns in the types of compounds detected and the concentrations they were detected at. As they report in the journal ACS Nano, the data from the breathalyzer could be used to accurately detect that a person is suffering from a unique disease nearly nine out of ten times. Read more of this story at Slashdot.