MIT crafts genetic circuits that remember their work through DNA

It’s easy to find work on gene-based storage ; finding genes that will do any of the heavy lifting is another matter. MIT believes it has a genetic circuit that will finally get to work, and then some. In using recombinase enzymes to alter DNA sequences serving as logic gates, researchers have developed a cellular circuit that not only mimics its silicon cousins, but has its own built-in memory. As the gate activation makes permanent changes to a given DNA sequence, any gate actions stay in memory for up to 90 generations — and will hang around even if the cell’s life is cut short. MIT sees its technique as having ultimate uses for areas where longer-term memory is important, such as environmental sensors, but could also see varying output values helping with digital-to-analog converters and other devices where there’s a need for more precision. While there’s no word on imminent plans for real-world use, the development raises the possibility of processors that could skip the traditional memory cache as they pass info down the family tree. Filed under: Science , Alt Comments Via: SciTechDaily Source: MIT

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MIT crafts genetic circuits that remember their work through DNA

Quadruple DNA Helix

Sometimes the double helix likes to mix it up! Scientists at the University of Cambridge, United Kingdom, have found that DNA at the end of chromosomes actually have a very different structure: instead of double-stranded, they have four strands. Balasubramanian’s group has been pursuing a four-stranded version of the molecule that scientists have produced in the test tube now for a number of years. It is called the G-quadruplex. The “G” refers to guanine, one of the four chemical groups, or “bases”, that hold DNA together and which encode our genetic information (the others being adenine, cytosine, and thymine). The G-quadruplex seems to form in DNA where guanine exists in substantial quantities. Jonathan Amos of BBC has the post: Link

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Quadruple DNA Helix

It Now Only Costs $100 To Know Everything About Your DNA

Mapping out your genome is the 21st Century equivalent of staring deep inside your soul; it’s tempting to look, but terrifying what you might find. The DNA divers at 23andMe are hoping that slashing the price of their home-testing service—from $300 down to $100—will be enough to tilt the scales towards discovery. Are they right? More »

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It Now Only Costs $100 To Know Everything About Your DNA

Fiber Optic Spanner (Wrench) Developed

xclr8r writes “A technique to use fiber optics to adjust microscopic particles has been developed. ‘Rather than an actual physical device that wraps around a cell or other microscopic particle to apply rotational force, the spanner (the British term for a wrench) is created when two laser beams — emitted by a pair of optical fibers — strike opposite sides of the microscopic object, trapping and holding it in place. By slightly offsetting the fibers, the beams can impart a small twisting force, causing the object to rotate in place. It is possible to create rotation along any axis and in any direction, depending on the positioning of the fibers.’ Applications of this technology can be used in a number of ways, including cancer research. This technology could be used to actually manipulate DNA. Associate Professor of Physics Samarendra Mohanty states that macroscale applications are a possibility, including ‘direct conversion of solar energy to mechanical energy,’ or possibly using it to ‘simulate an environment in which photons radiated from the sun could propel the reflective motors in solar sails, a promising future technology for deep-space travel.'” Read more of this story at Slashdot.

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Fiber Optic Spanner (Wrench) Developed

Behold, ALL the birds

By Robert T. Gonzalez Feast your eyes on the first complete evolutionary tree for all known modern bird species. It’s exhaustive, colorful, and beautiful to behold — a little like an avicular  Hillis Plot . But for all that this diagram tells us about birds’ evolutionary histories, what’s really interesting is what it says about how birds continue to evolve  today.  It’s Okay to be Smart ’s Joe Hanson explains: It was thought that any given species would expand and diversify quickly into subspecies (like the many different kinds of honeybees), soon maxing out its environment and filling all the ecological “niches”. Then, competition over limited resources would thin that down to the few most adaptable species. This tree says the opposite, that birds are continuing to diversify even today, and fast. The center of this tree, anchoring branches built using fossil and DNA sequence data, reaches back nearly 50 million years, to the earliest days of birds branching off of dinosaurs. Read the original study in  Nature , or these excellent synopses at  It’s Okay to be Smart  and  Science News . 

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Behold, ALL the birds