Hugh Pickens writes “Ariel Schwartz reports that researchers are working on an alcoholism vaccine that makes alcohol intolerable to anyone who drinks it. The vaccine builds on what happens naturally in certain people — about 20% of the Japanese, Chinese, and Korean population — with an alcohol intolerance mutation. Normally, the liver breaks down alcohol into an enzyme that’s transformed into the compound acetaldehyde (responsible for that nasty hangover feeling), which in turn is degraded into another enzyme. The acetaldehyde doesn’t usually have time to build up before it’s broken down. But people with the alcohol intolerance mutation lack the ability to produce that second enzyme; acetaldehyde accumulates, and they feel terrible. Dr. Juan Asenjo and his colleagues have come up with a way to stop the synthesis of that second enzyme via a vaccine, mimicking the mutation that sometimes happens naturally. ‘People have this mutation all over the world. It’s like how some people can’t drink milk,’ says Asenjo. Addressing the physiological part of alcohol addiction is just one piece of the battle. Addictive tendencies could very well manifest in other ways; instead of alcohol, perhaps former addicts will move on to cigarettes. Asenjo admits as much: ‘Addiction is a psychological disease, a social disease. Obviously this is only the biological part of it.'” Read more of this story at Slashdot.
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Alcoholism Vaccine Makes Alcohol Intolerable To Drinkers
New submitter razor88x writes “Although just 16% of Americans have purchased an e-book to date, the growth rate in sales of digital books is already dropping sharply. At the same time, sales of dedicated e-readers actually shrank in 2012, as people bought tablets instead. Meanwhile, printed books continue to be preferred over e-books by a wide majority of U.S. book readers. In his blog post Will Gutenberg Laugh Last?, writer Nicholas Carr draws on these statistics and others to argue that, contrary to predictions, printed books may continue to be the book’s dominant form. ‘We may be discovering,’ he writes, ‘that e-books are well suited to some types of books (like genre fiction) but not well suited to other types (like nonfiction and literary fiction) and are well suited to certain reading situations (plane trips) but less well suited to others (lying on the couch at home). The e-book may turn out to be more a complement to the printed book, as audiobooks have long been, rather than an outright substitute.'” Read more of this story at Slashdot. 
The social network is rumored to be amping up its video ads by adding in autoplay, audience targeting, and video expansion. [Read more] 
Entropy98 writes “Windows Live Messenger will be shut down by March 2013, after nearly 13 years of service, so Microsoft can focus its efforts on Skype, its recent $8.5bn acquisition. No word on whether users will be able to transfer their WLM accounts to Skype. ‘According to internet analysis firm Comscore, WLM still had more than double the number of Skype’s instant messenger facility at the start of this year and was second only in popularity to Yahoo Messenger. But the report suggested WLM’s US audience had fallen to 8.3 million unique users, representing a 48% drop year-on-year. By contrast, the number of people using Skype to instant message each other grew over the period.'” Read more of this story at Slashdot. 